Mining the Black Sea Microbiome for Producing Natural Bioactive Compounds
AbstractMarine microbiome is now recognized as an attractive source of bioactive compounds of pharmaceutical and biotechnological interest. The polyketides (PKs) and non-ribosomal peptides (NRPs) of marine microbial origin represent a significant proportion of bioactive natural products. The ecosystems of the brackish Black Sea host unique and highly diverse microbial communities. Despite having a great biodiversity, the biotechnological potential of microorganisms inhabiting these ecosystems remain mostly unexplored and unexploited. To explore this potential, marine microbial metagenomes collected in 2009 from the Romanian Black Sea sector were sequenced and mined for PKs and NRPs encoding genes. By using 16S rRNA high throughput sequencing (HTS)-based metagenomic approach in combination with an automated mining pipelines, we were able to show for the first time the great potential of Black Sea microbiome for secondary metabolite production, with special focus on NRPs and PKs of pharmaceutical importance.
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